明朝成化年间，朝纲腐败，奸邪当道
西厂东厂为宦官把持，混淆黑白，陷害忠良，朝野内外噤若寒蝉 时有赵怀安（李连杰 饰）等流亡剑客挺身而出，接连铲除东厂数名奸佞，致令阉贼胆战心惊 适值此时，风头正劲的西厂督主雨化田（陈坤 饰）出面干预 另一方面，宫女素慧容（范晓萱 饰）怀有身孕，绝命奔逃 被雨化田的爪牙追捕途中幸得神秘侠客凌雁秋（周迅 饰）相救 二人一路辗转逃往关外，来到曾经引起过腥风血雨的龙门客栈落脚 龙门客栈一如往昔，为凶险异常之所在 雨化田手下追赶至此，与先前而至的鞑靼商队剑拔弩张，关键时刻更有与雨化田长相极其相似的卜仓舟（陈坤 饰）与女侠客顾少棠（李宇春 饰）投宿客栈 不久，赵怀安一众也偷偷潜至龙门
各方势力云集于此，新的正邪之战即将展开，更有天大的秘密即将揭开……
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